Medicinal chemists need to understand the relationship between chemical structure and the physical properties of molecules and how this translates into compound stability and the interaction of the molecule with biological structures. These biological targets include proteins, lipids, nucleic acids and cell membranes. Interaction of the molecules with these targets affects the distribution of the compound in biological systems and modulates biological function.
To do this successfully the medicinal chemist needs to be aware of how target selection is carried out and how this affects lead generation. The medicinal chemist needs knowledge of structure property relationships, the physico-chemical properties of drugs and how these molecules interact with the body-pharmacokinetics and ADME (Absorption, Distribution, Metabolism and Excretion).
The course also includes an overview of the use of computational chemistry in virtual screening and library design. The lectures are backed up by a number of case studies and tutorial sessions, which involve the participants in using the concepts discussed.

药物化学课程介绍：

中文：药物化学是发现与发明新药、研究化学药物的制备方法、阐明药物的物理化学性质、药物分子与机体的相互作用、药物的结构与活性的关系的一门科学。在新药物的研究中，药物化学处于整个研究链条的最前端，需要高度创新能力和多个学科的广泛知识。药物化学课程涉及化学、生物学、生理学、细胞和分子生物学、免疫学等很多相关的学科知识。
通过本课程的教学，使学生掌握药物结构类型、药物化学结构与理化性质、药理作用、体内代谢之间的相互关系。熟悉药物制备原理，为有效合理使用现代化学药物提供理论依据。了解药物化学现代理论，为发展药物应用研究奠定基础。
本课程计划开设108学时，其中理论课62学时，实验课46学时。通过本课程考核者可获6学分。


English：
Medicinal chemists need to understand the relationship between chemical structure and the physical properties of molecules and how this translates into compound stability and the interaction of the molecule with biological structures. These biological targets include proteins, lipids, nucleic acids and cell membranes. Interaction of the molecules with these targets affects the distribution of the compound in biological systems and modulates biological function.
To do this successfully the medicinal chemist needs to be aware of how target selection is carried out and how this affects lead generation. The medicinal chemist needs knowledge of structure property relationships, the physico-chemical properties of drugs and how these molecules interact with the body-pharmacokinetics and ADME (Absorption, Distribution, Metabolism and Excretion).
The course also includes an overview of the use of computational chemistry in virtual screening and library design. The lectures are backed up by a number of case studies and tutorial sessions, which involve the participants in using the concepts discussed.



版权所有：南方医科大学药学院药物化学系
地址：广州市白云区南方医科大学
邮编：510515

英汉并不完全一一对应，但了解大意应无问题！